Asymptomatic Atherosclerosis Pathophysiology Detection And Treatment Pdf

asymptomatic atherosclerosis pathophysiology detection and treatment pdf

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Published: 24.05.2021

Coronary artery disease

Recent cardiovascular clinical trials have also shed more light upon the efficacy and safety of novel compounds targeting the main pathways of atherosclerosis and its cardiovascular complications. The focus of this update is on the pathophysiology and medical interventions of low-density lipoprotein cholesterol LDL-C , high-density lipoprotein cholesterol HDL-C , triglycerides TG and lipoprotein a Lp a. Main classical risk factors for atherosclerosis include dyslipoproteinaemia, diabetes, cigarette smoking, hypertension and genetic abnormalities. Hypercholesterolaemia is considered one of the main triggers of atherosclerosis. The increase in plasma cholesterol levels results in changes of the arterial endothelial permeability that allow the migration of lipids, especially LDL-C particles, into the arterial wall. Circulating monocytes adhere to the endothelial cells that express adhesion molecules, such as vascular adhesion molecule-1 VCAM-1 and selectins, and, consequently, migrate via diapedesis in the subendothelial space [ 1 ].

Coronary artery disease

Despite recent advances in the diagnosis and treatment of symptomatic atherosclerosis, available traditional screening methods for early detection and treatment of asymptomatic coronary artery disease are grossly insufficient and fail to identify the majority of victims prior to the onset of a life-threatening event. Morteza Naghavi and leading authorities from the Society for Heart Attack Prevention and Eradication SHAPE present a new paradigm for the screening and primary prevention of asymptomatic atherosclerosis. The text focuses on accurate, yet underutilized, measures of subclinical atherosclerosis, notably coronary artery calcium scanning and carotid intima-media thickness measurement. The authors introduce a comprehensive approach to identifying the vulnerable patients asymptomatic individuals at risk of a near future adverse event. Additional chapters discuss future directions towards containing the epidemic of atherosclerotic cardiovascular disease using innovative solutions such as preemptive interventional therapies bioabsorbable stents for stabilization of vulnerable atherosclerotic plaques, mass unconditional Polypill therapy for population-based risk reduction, and ultimately vaccination strategies to prevent the development of atherosclerosis. Up-to-date and authoritative, Asymptomatic Atherosclerosis: Pathophysiology, Detection, and Treatment is a must-have for any cardiologist or primary care physician who wishes to practice modern preventive cardiology and manage the increasing number of asymptomatic atherosclerotic patients.

Coronary artery disease CAD , also called coronary heart disease CHD , ischemic heart disease IHD , [13] or simply heart disease , involves the reduction of blood flow to the heart muscle due to build-up of plaque atherosclerosis in the arteries of the heart. Usually symptoms occur with exercise or emotional stress , last less than a few minutes, and improve with rest. Risk factors include high blood pressure , smoking , diabetes , lack of exercise, obesity , high blood cholesterol , poor diet, depression , and excessive alcohol. Ways to reduce CAD risk include eating a healthy diet , regularly exercising, maintaining a healthy weight, and not smoking. In , CAD affected million people and resulted in 8. The narrowing of coronary arteries reduces the supply of oxygen-rich blood flowing to the heart, which becomes more pronounced during strenuous activities during which the heart beats faster.

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Preventive Cardiology

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Anastasios Chatzikonstantinou, Marc E. Wolf, Anke Schaefer, Michael G. This was also reflected by the design of previous studies on the surgical versus conservative treatment and of current studies on interventional treatment versus surgery.

It seems that you're in Germany. We have a dedicated site for Germany. Despite recent advances in the diagnosis and treatment of symptomatic atherosclerosis, available traditional screening methods for early detection and treatment of asymptomatic coronary artery disease are grossly insufficient and fail to identify the majority of victims prior to the onset of a life-threatening event.

Asymptomatic and Symptomatic Carotid Stenosis: An Obsolete Classification?

David E. Atherosclerotic plaque rupture and resulting intracoronary thrombosis are thought to account for most acute coronary syndromes.

Но вот туфли - совсем другое. Даже во время учебы в колледже она старалась покупать самую лучшую обувь. Нельзя дотянуться до звезд, если чувствуешь себя ущемленной, - сказала как-то ее тетушка.

 Dov'ela plata. Где деньги. Беккер достал из кармана пять ассигнаций по десять тысяч песет и протянул мотоциклисту. Итальянец посмотрел на деньги, потом на свою спутницу. Девушка схватила деньги и сунула их в вырез блузки.

А вдруг это клиент. Новый клиент с севера. Он не допустит, чтобы какие-то страхи лишили его потенциального клиента.

 Сьюзан. По ее щеке скатилась слеза.

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