Nucleic Acids And Nucleotides Pdf

nucleic acids and nucleotides pdf

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Last reviewed: November An acidic, chainlike biological macromolecule consisting of multiple repeated units of phosphoric acid, sugar, and purine and pyrimidine bases. Nucleic acids Fig.

Biochemistry of Parasitic Protozoa pp Cite as. Nucleic acids are polymers of nucleotides. The latter are composed of a five-carbon sugar d -ribose or d -deoxyribose linked both to a nitrogen base purine or pyrimidine and a phosphate group nucleosides are nucleotides without this phosphate group.

Understanding biochemistry: structure and function of nucleic acids

Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides. Gives an overview of the chemistry and biology of nucleic acids in an easy-to-grasp manner.

Explains the connection between the structure of nucleic acids and their ability to form triple helical and quadruplex frameworks. EN English Deutsch. Your documents are now available to view.

Confirm Cancel. In: De Gruyter Textbook. De Gruyter About this book Life in all its forms is based on nucleic acids which store and transfer genetic information. Chemistry of Nucleic Acids.

Berlin, Boston: De Gruyter. Berlin, Boston: De Gruyter, Berlin, Boston: De Gruyter; Copy to clipboard. Log in Register. Full Access.

Why Study Nucleotide and Nucleic Acid Structure?

Nucleotides are required for a wide variety of biological processes and are constantly synthesized de novo in all cells. When cells proliferate, increased nucleotide synthesis is necessary for DNA replication and for RNA production to support protein synthesis at different stages of the cell cycle, during which these events are regulated at multiple levels. Therefore the synthesis of the precursor nucleotides is also strongly regulated at multiple levels. Nucleotide synthesis is an energy intensive process that uses multiple metabolic pathways across different cell compartments and several sources of carbon and nitrogen. The processes are regulated at the transcription level by a set of master transcription factors but also at the enzyme level by allosteric regulation and feedback inhibition. Here we review the cellular demands of nucleotide biosynthesis, their metabolic pathways and mechanisms of regulation during the cell cycle. The use of stable isotope tracers for delineating the biosynthetic routes of the multiple intersecting pathways and how these are quantitatively controlled under different conditions is also highlighted.


The monomeric units for nucleic acids are nucleotides. Nucleotides are made up of three structural subunits. 1. Sugar: ribose in RNA, 2-deoxyribose in DNA. 2.


Nucleic Acid Metabolism

Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides.

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Nucleic acids, deoxyribonucleic acid DNA and ribonucleic acid RNA , carry genetic information which is read in cells to make the RNA and proteins by which living things function. The well-known structure of the DNA double helix allows this information to be copied and passed on to the next generation. In this article we summarise the structure and function of nucleic acids. The article includes a historical perspective and summarises some of the early work which led to our understanding of this important molecule and how it functions; many of these pioneering scientists were awarded Nobel Prizes for their work. We explain the structure of the DNA molecule, how it is packaged into chromosomes and how it is replicated prior to cell division. We look at how the concept of the gene has developed since the term was first coined and how DNA is copied into RNA transcription and translated into protein translation.

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Nucleic Acid Metabolism

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