File Name: quality control of herbal medicine and standardization .zip
- Standardization and quality evaluation of herbal drugs
- Quality Control and Standardisation of Herbal Medicines
- Quality control of the traditional herbs and herbal products: a review
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Metrics details. Quality by design QbD is an advanced drug quality control concept that has been gradually implemented in the optimization of manufacturing processes of Chinese medicines. However, the variation of Chinese medicinal material quality has rarely been considered in published works. Because manufacturing processes may lower the variation introduced through different batches of materials, a material quality control strategy should be developed considering the influences of manufacturing processes. In this work, the processes of extraction, concentration, water precipitation, and chromatography for notoginseng total saponin NTS production were investigated while considering Panax notoginseng quality variation as a sample.
Standardization and quality evaluation of herbal drugs
Herbs and herbal products are of paramount importance for human health. To be able to guarantee safety and quality, standards and testing methods are needed. Pharmacopoeias contain quality control protocols setting the standards which are then required by governments.
The quality traits are many, including The quality traits are many, including the intrinsic variables of medicinal plant, e. On the other hand, many quality traits are related to agricultural conditions and practices, or to the harvesting and post-harvest processing. With so many variables, quality control of the end product becomes extremely complex, time consuming and costly.
To ensure the quality of medicinal plants for human consumption quality management -the use of "good practices" at each step, from seed to final product- becomes a crucial aspect. To ensure the quality of herbal medications, criteria such as botanical quality, type of preparation, physical constants, adulteration, contaminants, chemical constituents, pesticides residues et al.
Meanwhile, authentication of herbs is needed to avoid possible adulteration or contaminating plants, even toxic herbs such as Aristolochia species. Many of the methods are long standing, such as microscopy in combination with color reactions, but some 50 years ago chromatography developed as a major tool for both qualitative and quantitative analysis of herbal preparations. Nowadays, research is working on the improvement of these methods and on the development of novel tools.
For instance, next generation sequencing and mass spectrometry imaging, are emerging as new technologies for the quality control of herbal medicines. With these technologies, quick testing of herbal products and of mixed herbal powder preparations, including the testing for specific plant parts botanical drugs , can be achieved. Also, novel chemical tools such as metabolomics and Near Infrared Red NIR spectroscopy are being developed as powerful tools to identify and to link these with activity by using chemometric tools such as multivariate analysis.
Finally, progress of informatic tools such as machine learning helps to deal with the big data generated by sequencing or mass spectrometry. However, these new technologies, like all other new born technologies, should be tested and perfected for a broader range of products. This Research Topic will focus on the advanced technologies for herbal medicine quality control and standardization, including the aspects of botanical identification and chemical analysis.
We encourage studies focusing on the validation of such methods with the ultimate aim of including these in legally binding quality control protocols.
Advantages as well as limitations will be dealt with the aim to show what tools could be implemented for setting the standards of herbal preparations. Contributions on new technologies and their applications are welcome in this Research Topic. We hope this Research Topic will help to set the standards for the quality control and management of herbal medicines.
Purely biodiversity-based screening studies and studies of established natural products and their mechanism of action are outside the scope of this section. Studies reporting such local and traditional uses will only be accepted if the comply with the ConSEFS standards Heinrich et al. Toxicological research and clinical studies on medicinal plants are welcome.
Of course, full botanical documentation is essential i. Simple in silico and pharmacologically irrelevant assays for antioxidant activity e. Such assays are commonly used in food chemistry and other fields, but are not of pharmacological relevance. While impossible to define an exact cut-off, studies testing extracts at implausibly high doses are increasingly common in the literature.
Authors must consider the ethical acceptability of further in vivo studies on an already well-studied species, demonstrating some common activity e. Important Note : All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author. Overview Articles Authors Impact. About this Research Topic Herbs and herbal products are of paramount importance for human health.
Keywords : Herbal Medicines, Sequencing, Metabolome Important Note : All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements.
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Quality Control and Standardisation of Herbal Medicines
It stresses that there is a lack of research data and that the accepted limits suggested in the guidelines are referenced and extrapolated from work carried out in the food area. The problems are further compounded by the fact that there are literally s of companies world-wide offering various bands of the more commonly used herbal medicines that are of variable quality, with variable levels of the active ingredients. As self- medication by the public with these unregulated products has increased in recent years, there has been a concomitant increase in reported adverse effects, and hospital admission attributable to use of herbal preparation. Top Menu BiologyDiscussion. Rabies in Animals: Etiology, Treatment and Control. Top 4 Examples of Flavanones With Uses. This is a question and answer forum for students, teachers and general visitors for exchanging articles, answers and notes.
Standardization is an essential step in the development and production of herbal medicines in order to assure the reproducibility of quality, efficacy and safety.
Quality control of the traditional herbs and herbal products: a review
Metrics details. Herbal medicinal material and product need is increasing, and with this increase in the need, it is very much an essential requirement to maintain the quality of them. The quality of the herbals is altered by various physical, chemical, and geographical aspects which contribute to the quality of these materials. Apart from that, adulteration is also an increasing concern when it comes to herbal material quality.
The webinar will cover topics relating to regulation and review process of OTC drugs, Japanese Pharmacopoeia JP , quality management of herbal medicines.
Herbs and herbal products are of paramount importance for human health. To be able to guarantee safety and quality, standards and testing methods are needed. Pharmacopoeias contain quality control protocols setting the standards which are then required by governments. The quality traits are many, including The quality traits are many, including the intrinsic variables of medicinal plant, e.
Quality control of traditional Chinese medicines TCMs used clinically is becoming a challenge and has limited the development of TCM due to the high variability in concentration levels of active ingredients and markers as well as the lack of well-established criteria. Using Shengmai injection, which is a well-established TCM, as an example, we developed an integrated profiling approach that simultaneously captures the entire spectrum of ingredients and quantitatively determines the levels of seven key ingredients in the TCM product. This newly developed strategy showed that a panel of key ingredients or markers in the TCM product were relatively consistent within a statistically acceptable range. Therefore, this metabolomics-based approach will complement the current quality control standard using the concentration of several key ingredients or their total content and help improve the consistency and clinic efficacy of TCM products. Traditional Chinese medicine TCM is gaining greater acceptance throughout the world, especially in western countries, for improving health and preventing or healing diseases.
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